Nonerosive Reflux Disease

Nonerosive Reflux Disease (NERD) - An Update

Recognizing nonerosive reflux disease (NERD) as a distinct presentation of gastroesophageal reflux disease (GERD) was one of the most important developments in the field of GERD in the last decade. Whilst the definition of NERD has not changed significantly over the years, the disorder accounts for the majority of the GERD patients and those who failed proton pump inhibitor (PPI) treatment. Rec...

[Clinical characteristics and risk factors of reflux esophagitis: comparison with nonerosive reflux disease].

A systematic review and meta-analysis of the sex ratio for Barrett's esophagus, erosive reflux disease, and nonerosive reflux disease.

Barrett's esophagus is associated with reflux disease and substantially increases the risk of esophageal adenocarcinoma. The authors undertook a systematic review and meta-analysis of the sex ratio for Barrett's esophagus, erosive reflux disease (ERD), and nonerosive reflux disease (non-ERD) to compare these results with the sex ratio for esophageal adenocarcinoma. MEDLINE (US National Library ...

High Serum Pepsinogen I and Low Seroprevalence of in Chinese Patients with Nonerosive Reflux Disease

The prevalence of gastroesophageal reflux disease (GERD), including nonerosive reflux disease (NERD), is increasing in Asia where infection is highly endemic. The role of and pepsinogen (PG) has not been evaluated in most studies of NERD, and whether they play a role in GERD remains controversial. This study aimed to determine the demographic and serologic characteristics of Chinese patients wi...

Lansoprazole compared with ranitidine for the treatment of nonerosive gastroesophageal reflux disease.

BACKGROUND Traditionally, proton pump inhibitors are used primarily for patients with esophagitis. However, patients with nonerosive reflux disease may also benefit from these powerful medications. OBJECTIVE To compare the safety and symptom relief efficacy of lansoprazole with ranitidine therapy and with placebo. METHODS In 2 randomized, double-blind, multicenter trials of 901 patients wit...